Mesh Spot
Cover 4 Palms & Quarters Beater
If your opponent is playing a match coverage (such as Cover 4 Quarters, Cover 4 Palms, or Cover 4 Show 2), this setup will help exploit the match logic of the AI to get your RB wide open for a huge gain down the sidelines. In most cases, the match coverage will result in one defender having to choose between guarding the TE in the flat or the RB on the wheel, and most of the time they stick with the TE, leaving the RB unguarded down the sideline. In the rare event that the RB gets matched, throw to the unguarded TE in the flat.
Alignment
On a hash with the running back lined up on the short side of the field
Setup
Put the short side WR on a streak
Put the wide side TE on a curl
Put the short side TE on a flat route